|(1S,3aS,4aR,4bR,6aR,11S,11aR,11bR,13aS)-1-(呋喃-3-基)-4b,7,7,11a,13a-五甲基-3,5,9-三氧代十六氢氧杂环庚烷并[4',3':3,4]苯并[1,2-f]环氧乙烯并[2,3-d]异苯并吡喃-11-基乙酸酯|CsnPharm

CAS No.: 1063-77-0

诺米林 Catalog No. CSN11572

Synonyms: NSC 297134;诺米林

Nomilin is a natural product found in grapefruit seed and varying Citrus fruits with anti-proliferative activity and antioxidant activity.

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400-920-2911

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生物活性

实验方案

技术信息

生物活性

描述Nomilin (NOM) is a limonoid compound obtained from the extracts of citrus fruits. NOM treatment effectively mitigated oxidative stress and facilitated the expressions of Nrf2 and NQO1(NAD(P)H dehydrogenase [quinone] 1)^[3]. NOM pre-treatment suppressed the IL-1β-induced over-regulation of pro-inflammation factors, such as NO, IL-6, PGE2, iNOS, TNF-α and COX-2. Moreover, NOM also down-regulates the degradation of ECM induced by IL-1β. Furthermore, NOM delays the disease progression in the mouse OA (Osteoarthritis) model^[4]. Nomilin could inhibit the activation and nuclear translocation of antiapoptotic transcription factors such as nuclear factor (NF)-κB, CREB, and ATF-2 in B16F-10 cells^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9434 mL
- 9.7170 mL
- 19.4339 mL
- 5 mM
- 0.3887 mL
- 1.9434 mL
- 3.8868 mL
- 10 mM
- 0.1943 mL
- 0.9717 mL
- 1.9434 mL

技术信息

CAS号

1063-77-0

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C28H34O9

运输

蓝冰

分子量

514.56

别名

NSC 297134;诺米林

溶解度

DMSO	190.0 mg/mL (369.2 mM)
Water	insoluble

动物实验配方

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